MnTBAP Reduces Adiposity and Increases Bio‐markers for Mitochondrial Biogenesis
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چکیده
منابع مشابه
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.
Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are being investigated for their widespread health benefits. These benefits have generally been ascribed to its combination of antioxidant and anti-inflammatory activity, but recent in vitro evidence suggests that improved mitochondrial biogenesis could play an important role. In addition, the in vivo effects of...
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Abstract Background and Objectives Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly pla...
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42 43 A high fat diet can increase adiposity, leptin secretion, and plasma fatty acid concentration. In 44 hypertension, this scenario may accelerate cardiac hypertrophy and development of heart failure, 45 but could be protective by activating peroxisome proliferator-activated receptors and expression 46 of mitochondrial oxidative enzymes. We assessed the effects of a high-fat diet on the 47 d...
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Increased muscle mitochondria are largely responsible for the increased resistance to fatigue and health benefits ascribed to exercise training. However, very little attention has been given to the likely benefits of increased brain mitochondria in this regard. We examined the effects of exercise training on markers of both brain and muscle mitochondrial biogenesis in relation to endurance capa...
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BACKGROUND Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, the mechanism responsible for this adaptation are poorly understood. METHODS AND FINDINGS The current study was undertaken to examine muscle mitochondrial bioenergetics in response to caloric restriction al...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.1202.7